MaherLab

Salk Institute

Research Output

Publications

134 peer-reviewed publications.

Showing 134 publications

2026

4
Glomerular hyperfiltration and enhanced sensitivity to kidney ischemia reperfusion with a blunted KIM-1 response in young male aging-accelerated SAMP8 mice

Goodluck H.A., Kanoo S., Kim Y.C., …, Maher P.

American Journal of Physiology: Renal Physiology

Aging & Geroneuroprotection
Neuroprotective and anti-inflammatory activity of Wyethia species: therapeutic potential for neurodegenerative diseases

Sagbo I.J., Soriano-Castell D., Rebman J., …, Maher P.

Frontiers in Pharmacology, 16, 1740121

Natural ProductsOxytosis / Ferroptosis
Acid ceramidase modulates the lipid profile and exacerbates sensitivity to ferroptosis in WI-38 replicative senescent cells

Soriano-Castell D., Goujon M., Dar N.J., …, Maher P.

Cell Death & Disease

Aging & GeroneuroprotectionOxytosis / Ferroptosis

2025

12
Protection against Amyloid-β Aggregation and Ferroptosis/Oxytosis Toxicity by Arylpyrazolones: Alzheimer's Disease Therapeutics

Soares P., Rahaman M., Maher P., et al.

ACS Medicinal Chemistry Letters, 16(2), 294-300

Drug DiscoveryOxytosis / Ferroptosis
Editorial: Oxytosis/ferroptosis: unraveling the mechanisms and its multifaceted role in neurodegenerative diseases

Dar N.J., Soriano Castell D., Bhat S.A., …, Maher P.

Frontiers in Molecular Neuroscience, 17, 1547301

Oxytosis / Ferroptosis
Western diet exacerbates a murine model of Balkan nephropathy

Oe Y., Kim Y.C., Kanoo S., …, Maher P.

American Journal of Physiology: Renal Physiology, 328(1), F15-F28

Aging & Geroneuroprotection
Ferroptosis-related stress during aging and its relevance to disease

Maher P., Soriano-Castell D., Dar N.J., et al.

Geroscience

Aging & GeroneuroprotectionOxytosis / Ferroptosis
Gender-Dependent Cognitive and Metabolic Benefits Due to Glyoxalase 1 (Glo1) Overexpression in Age-Accelerated SAMP8 Mice

Dafre A.L., Taguchi T., Dayn Y., …, Maher P.

Antioxidants, 14(8)

Aging & Geroneuroprotection
Transcriptomic signatures of oxytosis/ferroptosis are enriched in Alzheimer's disease

Currais A., Sanchez K., Soriano-Castell D., …, Maher P.

BMC Biology, 23(1), 132

Drug DiscoveryOxytosis / Ferroptosis
Affinity-Based Protein Profiling Reveals IDH2 as a Mitochondrial Target of Cannabinol in Receptor-Independent Neuroprotection

Schaller E., Lamer S., Schlosser A., …, Maher P.

Chemistry, e202501143

Drug DiscoveryNatural ProductsOxytosis / Ferroptosis
Cannabinol (CBN) alleviates age-related cognitive decline by improving synaptic and mitochondrial health

Dar N.J., Currais A., Taguchi T., …, Maher P.

Redox Biology, 84, 103692

Drug DiscoveryNatural Products
Ferroptosis and Charcot-Marie-Tooth Disease 1A: Emerging Evidence for a Pathogenic Association

White J.B., Sanchez K.L., Currais A., …, Maher P.

Antioxidants, 14(3)

Oxytosis / Ferroptosis
Evidence of Oxytosis/Ferroptosis in Niemann-Pick Disease Type C

Sanchez K.L., Kim J., White J.B., …, Maher P.

International Journal of Molecular Sciences, 26(7)

Oxytosis / Ferroptosis
Acid ceramidase modulates the lipid profile and exacerbates sensitivity to ferroptosis in senescent cells

Soriano-Castell D., Goujon M., Dar N.J., …, Maher P.

Research Square

Aging & GeroneuroprotectionOxytosis / Ferroptosis

2024

7
The Flavonoid Fisetin Reduces Multiple Physiological Risk Factors for Dementia

Maher P.

Neurochemistry International, 105805

Drug DiscoveryNatural Products
CMS121: a novel approach to mitigate aging-related obesity and metabolic dysfunction

Dafre A.L., Zahid S., Probst J.J., …, Maher P.

Aging, 16

Aging & GeroneuroprotectionDrug Discovery
Fragment-based drug discovery and biological evaluation of novel cannabinol-based inhibitors of oxytosis/ferroptosis for neurological disorders

Liang Z., Candib A., Soriano-Castell D., …, Maher P.

Redox Biology, 72, 103138

Drug DiscoveryNatural Products
CMS121, a Novel Drug Candidate for the Treatment of Alzheimer's Disease and Age-Related Dementia

Currais A., Raschke W., Maher P.

Journal of Alzheimer's Disease, 101(s1), S179-S192

Aging & GeroneuroprotectionDrug Discovery

2023

4
Attenuation of Age-Related Hearing Impairment in Senescence-Accelerated Mouse Prone 8 (SAMP8) Mice Treated with Fatty Acid Synthase Inhibitor CMS121

Pham T.B., Boussaty E.C., Currais A., …, Maher P.

Journal of Molecular Neuroscience

Aging & GeroneuroprotectionDrug Discovery
The Geroprotective Drug Candidate CMS121 Alleviates Diabetes, Liver Inflammation, and Renal Damage in db/db Leptin Receptor Deficient Mice

Zahid S., Dafre A.L., Currais A., …, Maher P.

International Journal of Molecular Sciences, 24(7)

Aging & GeroneuroprotectionDrug Discovery
CMS121 Partially Attenuates Disease Progression in Mouse Models of Huntington's Disease

Ates G., Taguchi T., Maher P.

Molecular Neurobiology

Aging & GeroneuroprotectionDrug Discovery
REAP+: A single preparation for rapid isolation of nuclei, cytoplasm, and mitochondria

Dos Santos B., Bion M.C., Goujon-Svrzic M., …, Maher P.

Analytical Biochemistry, 115445

General

2022

6
Editorial: Psychoactive natural products: Potential in the treatment of brain diseases and strategies to improve delivery

Cabral C., Carbone C., Maher P., et al.

Frontiers in Pharmacology, 13, 1032496

Natural Products
A class of anti-inflammatory lipids decrease with aging in the central nervous system

Tan D., Konduri S., Erikci Ertunc M., …, Maher P.

Nature Chemical Biology

Aging & Geroneuroprotection
The Role of AMP-activated Protein Kinase (AMPK) in Oxytosis/Ferroptosis: Protector or Potentiator?

Currais A., Kepchia D., Liang Z., …, Maher P.

Antioxidants and Redox Signaling

Oxytosis / Ferroptosis
Cannabinol inhibits oxytosis/ferroptosis by directly targeting mitochondria independently of cannabinoid receptors

Liang Z., Soriano-Castell D., Kepchia D., …, Maher P.

Free Radical Biology & Medicine

Drug DiscoveryNatural ProductsOxytosis / Ferroptosis
The Alzheimer's disease drug candidate J147 decreases blood plasma fatty acid levels via modulation of AMPK/ACC1 signaling in the liver

Kepchia D., Huang L., Currais A., …, Maher P.

Biomedicine & Pharmacotherapy, 147, 112648

Aging & GeroneuroprotectionDrug Discovery

2021

6
Geroprotective effects of Alzheimer's disease drug candidates

Kepchia D., Currais A., Dargusch R., …, Maher P.

Aging, 13

Aging & GeroneuroprotectionDrug Discovery
Defining a Pharmacological Inhibitor Fingerprint for Oxytosis/Ferroptosis

Soriano-Castell D., Currais A., Maher P.

Free Radical Biology & Medicine

Oxytosis / Ferroptosis
Profiling the chemical nature of anti-oxytotic/ferroptotic compounds with phenotypic screening

Soriano-Castell D., Liang Z., Maher P., et al.

Free Radical Biology & Medicine, 313-325

Drug DiscoveryOxytosis / Ferroptosis
The search for anti-oxytotic/ferroptotic compounds in the plant world

Soriano-Castell D., Liang Z., Maher P., et al.

British Journal of Pharmacology

Oxytosis / Ferroptosis

2020

12
Targeting of intracellular Ca stores as a therapeutic strategy against age-related neurotoxicities

Goldberg J., Currais A., Ates G., …, Maher P.

NPJ Aging and Mechanisms of Disease, 6, 10

Aging & Geroneuroprotection
The Value of Herbarium Collections to the Discovery of Novel Treatments for Alzheimer's Disease, a Case Made With the Genus

Maher P., Fischer W., Liang Z., et al.

Frontiers in Pharmacology, 11, 208

Natural Products

Using Plants as a Source of Potential Therapeutics for the Treatment of Alzheimer's Disease

Maher P.A.

Yale J Biol Med, 93(2), 365-373

General
Intracellular amyloid toxicity induces oxytosis/ferroptosis regulated cell death

Huang L., McClatchy D.B., Maher P., et al.

Cell Death & Disease, 11(10), 828

Oxytosis / Ferroptosis
Natural products targeting mitochondria: emerging therapeutics for age-associated neurological disorders

Liang Z., Currais A., Soriano-Castell D., …, Maher P.

Pharmacology & Therapeutics, 107749

Aging & GeroneuroprotectionNatural Products
Using the Oxytosis/Ferroptosis Pathway to Understand and Treat Age-Associated Neurodegenerative Diseases

Maher P., Currais A., Schubert D.

Cell Chemical Biology

Aging & GeroneuroprotectionOxytosis / Ferroptosis

2019

6
Anticonvulsant and antiepileptogenic effects of system inactivation in chronic epilepsy models

Leclercq K., Liefferinge J.V., Albertini G., …, Maher P.

Epilepsia, 60(7), 1412-1423

General
Old age-associated phenotypic screening for Alzheimer's disease drug candidates identifies sterubin as a potent neuroprotective compound from Yerba santa

Fischer W., Currais A., Liang Z., …, Maher P.

Redox Biology, 21, 101089

Aging & GeroneuroprotectionDrug DiscoveryNatural Products
Efficacy of Cannabinoids in a Pre-Clinical Drug-Screening Platform for Alzheimer's Disease

Schubert D., Kepchia D., Liang Z., …, Maher P.

Molecular Neurobiology, 56(11), 7719-7730

Drug Discovery
The Potential of Flavonoids for the Treatment of Neurodegenerative Diseases

Maher P.

International Journal of Molecular Sciences, 20(12)

Natural Products
Rapid and persistent loss of TXNIP in HT22 neuronal cells under carbonyl and hyperosmotic stress

Dafre A.L., Schmitz A.E., Maher P.

Neurochemistry International, 104585

General

2018

6
Geroneuroprotectors: Effective Geroprotectors for the Brain

Schubert D., Currais A., Goldberg J., …, Maher P.

Trends in Pharmacological Sciences, 39(12), 1004-1007

Aging & Geroneuroprotection
Oxytosis/Ferroptosis-(Re-) Emerging Roles for Oxidative Stress-Dependent Non-apoptotic Cell Death in Diseases of the Central Nervous System

Lewerenz J., Ates G., Methner A., …, Maher P.

Frontiers in Neuroscience, 12, 214

Oxytosis / Ferroptosis
Regioselective synthesis of 7-O-esters of the flavonolignan silibinin and SARs lead to compounds with overadditive neuroprotective effects

Schramm S., Huang G., Gunesch S., …, Maher P.

European Journal of Medicinal Chemistry, 146, 93-107

Natural Products
The mitochondrial ATP synthase is a shared drug target for aging and dementia

Goldberg J., Currais A., Prior M., …, Maher P.

Aging Cell, 17(2)

Aging & Geroneuroprotection

2017

9
Intraneuronal protein aggregation as a trigger for inflammation and neurodegeneration in the aging brain

Currais A., Fischer W., Maher P., et al.

FASEB Journal, 31(1), 5-10

Aging & Geroneuroprotection
Absence of system xc(-) on immune cells invading the central nervous system alleviates experimental autoimmune encephalitis

Merckx E., Albertini G., Paterka M., …, Maher P.

Journal of Neuroinflammation, 14(1), 9

Oxytosis / Ferroptosis
Lack of interleukin-13 receptor α1 delays the loss of dopaminergic neurons during chronic stress

Mori S., Sugama S., Nguyen W., …, Maher P.

Journal of Neuroinflammation, 14(1), 88

General
Methylglyoxal-Induced Protection Response and Toxicity: Role of Glutathione Reductase and Thioredoxin Systems

Schmitz A.E., de Souza L.F., Dos Santos B., …, Maher P.

Neurotoxicity Research, 32(3), 340-350

General
The role of Ca(2+) in cell death caused by oxidative glutamate toxicity and ferroptosis

Maher P., van Leyen K., Dey P.N., et al.

Cell Calcium, 70, 47-55

Oxytosis / Ferroptosis
Fisetin Reduces the Impact of Aging on Behavior and Physiology in the Rapidly Aging SAMP8 Mouse

Currais A., Farrokhi C., Dargusch R., …, Maher P.

The Journals of Gerontology: Series A, 73(3), 299-307

Aging & GeroneuroprotectionNatural Products
A novel Alzheimer's disease drug candidate targeting inflammation and fatty acid metabolism

Daugherty D., Goldberg J., Fischer W., …, Maher P.

Alzheimer's Research & Therapy, 9(1), 50

Drug Discovery

2016

4
Amyloid proteotoxicity initiates an inflammatory response blocked by cannabinoids

Currais A., Quehenberger O., M Armando A., …, Maher P.

NPJ Aging and Mechanisms of Disease, 2, 16012

General
Neuroimmunology of the Interleukins 13 and 4

Mori S., Maher P., Conti B.

Brain Sci, 6(2)

General
Dietary glycemic index modulates the behavioral and biochemical abnormalities associated with autism spectrum disorder

Currais A., Farrokhi C., Dargusch R., …, Maher P.

Molecular Psychiatry, 21(3), 426-36

General
Global quantitative analysis of phosphorylation underlying phencyclidine signaling and sensorimotor gating in the prefrontal cortex

McClatchy D.B., Savas J.N., Martínez-Bartolomé S., …, Maher P.

Molecular Psychiatry, 21(2), 205-15

General

2015

6
Characterization of the neuroprotective potential of derivatives of the iron chelating drug deferiprone

Maher P., Kontoghiorghes G.J.

Neurochemical Research, 40(3), 609-20

Natural Products

How fisetin reduces the impact of age and disease on CNS function

Maher P.

Frontiers in Bioscience, 7, 58-82

Natural Products
Cell and brain tissue imaging of the flavonoid fisetin using label-free two-photon microscopy

Krasieva T.B., Ehren J., O'Sullivan T., …, Maher P.

Neurochemistry International, 89, 243-8

Natural Products
A comprehensive multiomics approach toward understanding the relationship between aging and dementia

Currais A., Goldberg J., Farrokhi C., …, Maher P.

Aging, 7(11), 937-55

Aging & Geroneuroprotection
Methylglyoxal, the foe and friend of glyoxalase and Trx/TrxR systems in HT22 nerve cells

Dafre A.L., Goldberg J., Wang T., …, Maher P.

Free Radical Biology & Medicine, 89, 8-19

General
Chronic Glutamate Toxicity in Neurodegenerative Diseases-What is the Evidence?

Lewerenz J., Maher P.

Frontiers in Neuroscience, 9, 469

General

2014

4
Screening and identification of neuroprotective compounds relevant to Alzheimer's disease from medicinal plants of S. Tomé e Príncipe

Currais A., Chiruta C., Goujon-Svrzic M., …, Maher P.

Journal of Ethnopharmacology, 155(1), 830-40

Natural Products
Back to the future with phenotypic screening

Prior M., Chiruta C., Currais A., …, Maher P.A.

ACS Chemical Neuroscience, 5(7), 503-13

Drug Discovery
Modulation of p25 and inflammatory pathways by fisetin maintains cognitive function in Alzheimer's disease transgenic mice

Currais A., Prior M., Dargusch R., …, Maher P.

Aging Cell, 13(2), 379-90

Natural Products

Proteasome Assay in Cell Lysates

Maher P.

Bio-protocol, 4(2)

General

2013

3
Functional consequences of age-dependent changes in glutathione status in the brain

Currais A., Maher P.

Antioxidants and Redox Signaling, 19(8), 813-22

General
Modulation of 5-lipoxygenase in proteotoxicity and Alzheimer's disease

Valera E., Dargusch R., Maher P.A., et al.

Journal of Neuroscience, 33(25), 10512-25

General

2012

4
Diabetes exacerbates amyloid and neurovascular pathology in aging-accelerated mice

Currais A., Prior M., Lo D., …, Maher P.

Aging Cell, 11(6), 1017-26

Aging & Geroneuroprotection
An alternative approach to drug discovery for Alzheimer's disease dementia

Schubert D., Maher P.

Future Medicinal Chemistry, 4(13), 1681-8

Drug Discovery
Chemical modification of the multitarget neuroprotective compound fisetin

Chiruta C., Schubert D., Dargusch R., …, Maher P.

Journal of Medicinal Chemistry, 55(1), 378-89

Natural Products

2011

5
Fisetin lowers methylglyoxal dependent protein glycation and limits the complications of diabetes

Maher P., Dargusch R., Ehren J.L., et al.

PLOS ONE, 6(6), e21226

Natural Products
De-Risking of Stilbazulenyl Nitrone (STAZN), a Lipophilic Nitrone to Treat Stroke Using a Unique Panel of In Vitro Assays

Lapchak P.A., Schubert D.R., Maher P.A.

Translational Stroke Research, 2(2), 209-17

Drug Discovery
ERK activation by the polyphenols fisetin and resveratrol provides neuroprotection in multiple models of Huntington's disease

Maher P., Dargusch R., Bodai L., et al.

Human Molecular Genetics, 20(2), 261-70

Natural Products
Delayed treatment with a novel neurotrophic compound reduces behavioral deficits in rabbit ischemic stroke

Lapchak P.A., Schubert D.R., Maher P.A.

Journal of Neurochemistry, 116(1), 122-31

Drug Discovery
A novel neurotrophic drug for cognitive enhancement and Alzheimer's disease

Chen Q., Prior M., Dargusch R., …, Maher P.

PLOS ONE, 6(12), e27865

Drug Discovery

2010

1
A pyrazole derivative of curcumin enhances memory

Maher P., Akaishi T., Schubert D., et al.

Neurobiology of Aging, 31(4), 706-9

Natural Products

2009

6
Basal levels of eIF2alpha phosphorylation determine cellular antioxidant status by regulating ATF4 and xCT expression

Lewerenz J., Maher P.

Journal of Biological Chemistry, 284(2), 1106-15

Oxytosis / Ferroptosis
Neural cells secrete a unique repertoire of proteins

Schubert D., Herrera F., Cumming R., …, Maher P.

Journal of Neurochemistry, 109(2), 427-35

General
Synaptojanin-1 plays a key role in astrogliogenesis: possible relevance for Down's syndrome

Herrera F., Chen Q., Fischer W.H., …, Maher P.

Cell Death and Differentiation, 16(6), 910-20

General
Induction of Nrf2 and xCT are involved in the action of the neuroprotective antibiotic ceftriaxone in vitro

Lewerenz J., Albrecht P., Tien M.L., …, Maher P.

Journal of Neurochemistry, 111(2), 332-43

Oxytosis / Ferroptosis
Modulation of multiple pathways involved in the maintenance of neuronal function during aging by fisetin

Maher P.

Genes & Nutrition, 4(4), 297-307

Aging & GeroneuroprotectionNatural Products
Metabolic links between diabetes and Alzheimer's disease

Maher P.A., Schubert D.R.

Expert Review of Neurotherapeutics, 9(5), 617-30

General

2008

6
Flavonoids protect retinal ganglion cells from ischemia in vitro

Maher P., Hanneken A.

Experimental Eye Research, 86(2), 366-74

Natural Products
A novel approach to enhancing cellular glutathione levels

Maher P., Lewerenz J., Lozano C., et al.

Journal of Neurochemistry, 107(3), 690-700

General
A broadly neuroprotective derivative of curcumin

Liu Y., Dargusch R., Maher P., et al.

Journal of Neurochemistry, 105(4), 1336-45

Natural Products

2007

2
A novel approach to screening for new neuroprotective compounds for the treatment of stroke

Maher P., Salgado K.F., Zivin J.A., et al.

Brain Research, 1173, 117-25

Drug Discovery

2006

3
Redox control of neural function: background, mechanisms, and significance

Maher P.

Antioxidants and Redox Signaling, 8(11-12), 1941-70

General
Flavonoid fisetin promotes ERK-dependent long-term potentiation and enhances memory

Maher P., Akaishi T., Abe K.

Proceedings of the National Academy of Sciences of the United States of America, 103(44), 16568-73

Natural Products

2005

4
Uncoupling protein 2 protects dopaminergic neurons from acute 1,2,3,6-methyl-phenyl-tetrahydropyridine toxicity

Conti B., Sugama S., Lucero J., …, Maher P.

Journal of Neurochemistry, 93(2), 493-501

General
The molecular basis of oxidative stress-induced cell death in an immortalized retinal ganglion cell line

Maher P., Hanneken A.

Investigative Ophthalmology & Visual Science, 46(2), 749-57

General
The effects of stress and aging on glutathione metabolism

Maher P.

Ageing Research Reviews, 4(2), 288-314

Aging & Geroneuroprotection
Flavonoids protect retinal ganglion cells from oxidative stress-induced death

Maher P., Hanneken A.

Investigative Ophthalmology & Visual Science, 46(12), 4796-803

Natural Products

2003

1
The regulation of glucose metabolism by HIF-1 mediates a neuroprotective response to amyloid beta peptide

Soucek T., Cumming R., Dargusch R., …, Maher P.

Neuron, 39(1), 43-56

General

2001

3

Oxytosis: A novel form of programmed cell death

Tan S., Schubert D., Maher P.

Current Topics in Medicinal Chemistry, 1(6), 497-506

Oxytosis / Ferroptosis
Presenilin binding protein is associated with neurofibrillary alterations in Alzheimer's disease and stimulates tau phosphorylation

Chen Q., Yoshida H., Schubert D., …, Maher P.

American Journal of Pathology, 159(5), 1597-602

General

Regulation of antioxidant metabolism by translation initiation factor 2alpha

Tan S., Somia N., Maher P., et al.

Journal of Cell Biology, 152(5), 997-1006

General

2000

1

Signaling by reactive oxygen species in the nervous system

Maher P., Schubert D.

Cellular and Molecular Life Sciences, 57(8-9), 1287-305

General

1998

4

Cellular mechanisms of resistance to chronic oxidative stress

Sagara Y., Dargusch R., Chambers D., …, Maher P.

Free Radical Biology & Medicine, 24(9), 1375-89

General

The regulation of reactive oxygen species production during programmed cell death

Tan S., Sagara Y., Liu Y., …, Maher P.

Journal of Cell Biology, 141(6), 1423-32

General
Phosphatidylcholine-specific phospholipase C regulates glutamate-induced nerve cell death

Li Y., Maher P., Schubert D.

Proceedings of the National Academy of Sciences of the United States of America, 95(13), 7748-53

General

Mechanisms of resistance to oxidative stress in Alzheimer's disease

Sagara Y., Tan S., Maher P., et al.

Biofactors, 8(1-2), 45-50

General

1997

3

Requirement for cGMP in nerve cell death caused by glutathione depletion

Li Y., Maher P., Schubert D.

Journal of Cell Biology, 139(5), 1317-24

Oxytosis / Ferroptosis

The role of protein phosphorylation in beta amyloid toxicity

Tan S., Maher P., Schubert D.

Brain Research, 765(1), 159-63

General

A role for 12-lipoxygenase in nerve cell death caused by glutathione depletion

Li Y., Maher P., Schubert D.

Neuron, 19(2), 453-63

Oxytosis / Ferroptosis

1992

1

Growth factors and vitamin E modify neuronal glutamate toxicity

Schubert D., Kimura H., Maher P.

Proceedings of the National Academy of Sciences of the United States of America, 89(17), 8264-7

General